Clinical significance of plasma Lp-PLA2 and D-dimeric detection in lung cancer patients

Objective To investigate the clinical significance of detecting plasma levels of lipoprotein-related phospholipase A2 (Lp-PLA2) and D-Dimer (D-D) in patients with lung cancer. Methods A total of 120 lung cancer patients, which were hospitalized in the Second People’s Hospital of Lianyungang from July 2016 to May 2018, were randomly selected and divided into group A (34 to 54 years old, 20 cases) and group B (55 to 84 years old, 100 cases), according to their ages. Among the enrolled patients, 46 cases were in T2 stage and 74 cases were in T3 stage, according to topography, lymph node and metastasis classification. The levels of Lp-PLA2 and D-D of the two groups were detected, and the results were analyzed by logistic analysis and multivariate regression analysis. Results Levels of plasma Lp-PLA2 and D-D levels were statistically different among patients with different ages (P<0.05), and they were also significantly different between patients at different cancer TNM stages (P<0.05). Logistic analysis showed Lp-PLA2 and D-D levels were correlated with age and TNM stages in patients with lung cancer (P=0.009, 0.002; 95% CI: 1.007-1.069, 2.621-12.168). Conclusions Detection of plasma Lp-PLA2 and D-D levels is conductive to understanding of severity of lung cancer, so as to provide a reliable basis for patients’ clinical treatment. Key words: Lung cancer; Lipoprotein-related phospholipase A2; D-Dimer