Clinical research of memantine combined with nimodipine on senile elderly vascular dementia

Objective To explore the clinical efficacy and safety of memantine combined with nimodipine in improving cognitive function and behavioral capacity in senile elderly vascular dementia patients.Methods Fifty senile elderly vascular dementia patients with Minimental State Examination(MMSE)scores between 7 and 20 were randomly divided into 3 groups.MMSE,Activit of Daily Livings Scale(ADL) and Clinical Dementia Rating Scale(CDR) scores were assessed before treatment and after 12 weeks of treatment.A comparative study was made to evalate the curative effects and side effects between the 3 groups.Results MMSE and ADL scores of memantine group(18.7±4.5,30.7±11.5,respectively) improved significantly when compared with control group(15.9±4.6,34.9±11.8,respectively),and the difference was significant(P(0.05)).There was a significant difference in MMSE and ADL scores between combined group(21.2±3.9,(26.5)±10.6,respectively) and memantine group(P0.05).The incidence of adverse reactions showed no difference between 3 groups(P0.05).Conclusion Memantine can effectively improve the cognitive function and daily living skills in senile elderly vascular dementia patients.Its combination with nimodipine is superior to its single use with a higher safety.