Phase II trial of iproplatin in advanced squamous cell carcinoma of the head and neck, oesophagus and lung

whether a multi-drug regimen containing fluorouracil (FU) is more effective than FU alone. Cullinan et al. have recently investigated polychemotherapy in a randomised study but failed to demonstrate any significant improvement in survival [9]. Our study shows that epirubicin, VPI6 and C D D P combination is ineffective in inducing objective responses in patients with advanced pancreatic carcinoma.