Interferon combined with antiviral drug for herpes simplex viral keratitis

Objective To evaluate the clinical efficacy of intramuscular and subconjunctival injection of interferon combined with antiviral drugs in the treatment of herpes simplex viral keratitis.Methods A total of 73 patients(79 eyes) were collected,and randomly divided into treatment group(45 eyes) and control group(34 eyes).Acyclovir eye drop(1 g·L-1) was administrated in the control group for 6 to 8 times daily.Besides the same treatment as control group,100 thousands units interferon were administrated by subconjunctival injection for 6 to 8 times totally,once everyday or each two days,1 mL one time.Intramuscular injection of 1 million unites interferon was administrated at the same time in adult and 1 million U·m-2 in children,6 to 8 times totally and once each two days.Results The curative rate was 75.6% in treatment group,and 47.1% in control group.The total effective rate was 95.6% in treatment group,and 64.7% in control group.There were significant differences in curative rates and total effective rates between the two groups(both P0.05).Visual acuity of 43 eyes increased in treatment group,and 22 eyes in control group(P0.05).Conclusion Intramuscular and subconjunctival injection of interferon combined with antiviral drug is with high curative rate,seldom side effects and good clinical results for herpes simplex viral keratitis.