A 37.37μW-Per-Cell Multifunctional Automated Nanopore Sequencing CMOS Platform with 16∗8 Biosensor Array

Nanopore-based DNA sequencing technology has become one of the most promising sequencing approaches with its advantages of label-free and low cost. However, most of the biosensor systems for nanopore sequencing only perform passive detection which is merely part of the overall function of a practical DNA sequencing platform. In this paper, a multifunctional automated integrated CMOS platform for nanopore-based DNA sequencing is presented. The platform equipped with 16∗8 biosensor array for nanopore detection is also able to perform bilayer lipid membrane capacitance detection and nanopore insertion pulse generation, realizing the whole process automated auxiliary function from transducer preparation to DNA sequencing. Post layout simulation shows that each cell consumes only 37.366μW while the whole system occupying 1.633mm2.