Prostaglandin E and F content of the amniotic fluid in various stages of beginning labor

: Levels of prostaglandin (PG) E- and F-equivalents determined radio-immunologically in amniotic fluid from women with uncomplicated pregnancies at term were related to the cervical state and the onset of regular labour. The lowest levels of both PG E- and F-equivalents with about 400 pg/ml were measured in the group with an immature cervix. An about twofold increase of both PG's appears characteristic for the cervical ripening, whereas the readiness for the initiation of regular uterine contractions is apparently indicated by further raises of PG F2 alpha. At the beginning of parturition distinct elevations can be registered for both PG's with a dominance of PG F. From their dynamics in amniotic fluid conclusions about different functions of PG's during the period preceding labour can be drawn.