Combination of 5-Aminolevulinic acid photodynamic therapy and isotretinoin to treat moderate-to-severe acne.

Abstract Background In China, photodynamic therapy(PDT) has been widely accepted in the treatment of acne. However, there are few studies on PDT combined with isotretinoin of moderate to severe acne. Aims To evaluate the efficacy and safety of PDT combined with isotretinoin in the treatment of moderate to severe acne. Methods 70 cases of moderate and severe acne patients were randomly divided into PDT group and combination group. In combination group, patients were treated with PDT, once/2weeks, for 3 times; and oral isotretinoin, 10 mg twice a day for 3 months. The PDT group was treated with PDT alone. The skin lesions were counted before treatment and in the 4th, 6th, 8th, and 12th weeks to evaluate the clinical efficacy. Adverse reactions during the treatment were recorded. We monitored the liver function of the combination group once a month. The recurrence rate was recorded 6 months after treatment. Results A total of 67 patients completed the study. The effective rates of combination group in the 4th, 6th, 8th, and 12th weeks of treatment were 28.6%, 71.4%, 91.4%, and 94.1%, respectively; the effective rates of PDT group in the 4th, 6th, 8th, and 12th weeks of treatment were 22.9%, 54.3%, 74.3%, and 78.8%, respectively; the effective rates of two groups were statistically significant in the 6th, 8th, and 12th weeks of treatment (P  Conclusion PDT combined with isotretinoin has higher effective rate and lower recurrence rate than single PDT, is a new choice for the treatment of moderate to severe acne.