Ad26/MVA therapeutic vaccination with TLR7 stimulation in SIV-infected rhesus monkeys

Erica N. Borducchi,Crystal Cabral,Kathryn E. Stephenson,Jinyan Liu,Peter Abbink,David Nganga,Joseph P. Nkolola,Amanda L. Brinkman,Lauren Peter,Benjamin C. Lee,Jessica Jimenez,David Jetton,Jade Mondesir,Shanell Mojta,Abishek Chandrashekar,Katherine Molloy,Galit Alter,Jeffrey M. Gerold,Alison L. Hill,Mark G. Lewis,Maria G. Pau,Hanneke Schuitemaker,Joseph Hesselgesser,Romas Geleziunas,Jerome H. Kim,Merlin L. Robb,Nelson L. Michael,Dan H. Barouch

Ad26/MVA therapeutic vaccination with TLR7 stimulation in SIV-infected rhesus monkeys

2016

A combination of therapeutic vaccination with Ad26/MVA and stimulation of innate immune responses leads to improved virologic control and delayed rebound in SIV-infected macaques following discontinuation of antiretroviral therapy.

Keywords:

TLR7
Stimulation
Vaccination
Discontinuation
Innate immune system
Virology
Retrovirus
Immunology
Medicine
Vector vaccine
Adenoviridae
Immune system
Modified vaccinia Ankara
Viral load

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