The effect of percutaneous drainage using tiny incisions on the inflammatory factors in chronic venous insufficiency combined with lipodermatosclerosis of the lower extremities.

OBJECTIVE To explore the efficacy of percutaneous drainage with tiny incisions in chronic venous insufficiency (CVI) combined with lipodystrophy syndrome (LDS) of the lower extremities and its effect on the inflammatory factors. METHODS Sixty patients with CVI and LDS hospitalized for surgical treatment in Jiading District Central Hospital were recruited as the study cohort and randomly divided into a control group and an experimental group. The control group (n = 30) underwent varicose vein stripping in the lower extremities, while the experimental group (n = 30) was additionally treated with percutaneous drainage with tiny incisions for LDS. The efficacy of the two treatments, the mRNA expressions of collagen type I alpha 1 chain 1 (COL1A1), the lower limb circumferences, the subcutaneous thicknesses, the transcutaneous partial pressure of oxygen (TcPO2), the venous clinical severity scores (VCSS), the serum i TGF-β1, TNF-α, IL-2R, and IL-1β levels, the soluble intercellular adhesion molecule-1 (sICAM-1) levels, the soluble vascular cell adhesion molecule-1 (sVCAM-1) levels, and the quality of life scores (CIVIQ) were compared. RESULTS The total effective rate in the experimental group was 93.33% (28/30), which was higher than the rate of 73.33% (22/30) in the control group (P < 0.05). The experimental group exhibited shorter ankle circumferences and calf circumferences, smaller subcutaneous thicknesses, lower VCSS scores, lower sICAM-1, sVCAM-1, TGF-β1, TNF-α, IL-1β, IL-2R, and COL1A1 levels, and higher ABI and TcPO2 levels, and higher CIVIQ scores than the control group at 6 months after the treatment (P < 0.05). CONCLUSION Percutaneous drainage with tiny incisions has a high efficacy for CVI with LDS, and it can relieve the condition, inhibit the expression of adhesion molecules as well as the inflammatory response, improve the microcirculation of the lower extremities, reduce COL1A1 expression, and improve the quality of life.