[Effects of early intervention of second-look office hysteroscopy in the prevention of adhesion reformation for moderate-severe Asherman's syndrome].

Objective To compare the efficacy of different time interval in the prevention of adhesion reformation after hysteroscopic adhesiolysis for moderate-severe Asherman′s syndrome. Methods A total of 125 women with moderate-severe Asherman′s syndrome undergoing hysteroscopic division of intrauterine adhesion were enrolled into this retrospective cohort study.All patients underwent second-look hysteroscopy after a certain period of the first hysteroscopic adhesiolysis, and the operation would be performed again if any adhesion existed.According to the different time interval of hysteroscopy examination, they were divided into 3 groups: A: 2 months (n=36).The effect of hysteroscopic adhesiolysis was evaluated by American Fertility Society (AFS) score. Results The AFS score decreased significantly after hysteroscopic adhesiolysis in each group and the normal uterine rate was up to 64.8%.The median of decreased AFS score and normal uterine rate were as follows:group A:7 point and 78%, group B:7 point and 66.7%, group C:5 point and 44.4%.And groups A and B achieved significantly (P<0.01) greater reductions in the adhesion score than that of group C.The median time of recovery to normal uterine cavity were 1.64,2.75 and 5.26 months in each group and great differences existed among them (P<0.01). Conclusion The time interval of second-look hysteroscopy less than 1 month offers a better prognosis in the prevention of adhesion reformation for moderate-severe Asherman′s syndrome. Key words: Asherman′ssyndrome; Hysteroscopy; Adhesiolysis; Prognosis; Time