Pheromone biosynthesis activating neuropeptide

Abstract The discovery, history, function, and signal transduction pathways of PBAN are described here. PBAN is a peptide hormone that is produced by the brain-subesophageal ganglion (Br-SG) complex and activates the pheromone biosynthesis of lepidopteran sex pheromone glands. PBAN is a member of the FXPRLamide peptide family and is processed from a precursor peptide encoded by the DH-PBAN gene. The PBAN receptor is a GPCR that responds similarly to PBAN and some other FXPRLamide peptides, including the diapause hormone, as determined by functional assays using PBAN receptor-expressing cells.