Butorphanol significantly suppresses fentanyl-induced cough during general anesthesia induction

Objective To evaluate the effects of pre-induction butorphanol administration on fentanyl-induced cough during anesthesia induction. Methods This was a random,double-blind study.One hundred and sixty elective surgical patients were equally and randomly assigned to one of the following groups in which butorphnol or equal volume normal saline(control) was injected through peripheral cannula 1 minute prior to intravenous administration of 3 μg/kg fentanyl in 3 seconds.The grade of cough and hemodynamics during the procedure were recorded. Results Only 2(2.50%)patients had mild to moderate cough in pre-treatment butorphanol group,while 23(28.75%)patients in control group coughed after giving fentanyl intravenously,in which there were 5 mild cases(6.25%),14 moderate(17.5%),and 7 severe(8.75%).Compared with the control group,pre-induction butorphanol did not influenced heart rate(HR) and mean arterial pressure(MAP) before tracheal intubation,but significantly suppressed increase of HR and MAP caused by intubation. Conclusions Butorphanol pre-treatment significantly suppresses 3 μg/kg fentanyl-induced cough during anesthesia induction.