Pleiotropy of systemic lupus erythematosus risk alleles and cardiometabolic disorders: A phenome-wide association study and inverse-variance weighted meta-analysis.

Vivian K Kawai,Mingjian Shi,Ge Liu,QiPing Feng,Wei-Qi Wei,Cecilia P. Chung,Theresa L. Walunas,Adam S. Gordon,James G. Linneman,Scott J. Hebbring,John B. Harley,Nancy J. Cox,Dan M. Roden,C. Michael Stein,Jonathan D. Mosley

Pleiotropy of systemic lupus erythematosus risk alleles and cardiometabolic disorders: A phenome-wide association study and inverse-variance weighted meta-analysis.

2021

Vivian K Kawai
Mingjian Shi
Ge Liu
QiPing Feng
Wei-Qi Wei
Cecilia P. Chung
Theresa L. Walunas
Adam S. Gordon
James G. Linneman
Scott J. Hebbring
John B. Harley
Nancy J. Cox
Dan M. Roden
C. Michael Stein
Jonathan D. Mosley

ObjectivesTo test the hypothesis that genetic predisposition to systemic lupus erythematosus (SLE) increases the risk of cardiometabolic disorders.MethodsUsing 41 single nucleotide polymorphisms (S...

Keywords:

Phenome
risk allele
Pleiotropy
Bioinformatics
Meta-analysis
Medicine
Single-nucleotide polymorphism
Genetic predisposition

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