A new Epstein-Barr virus negative Burkitt's lymphoma derived cell-line: I. Analysis of cell surface markers and abnormal expression of HLA antigens

CHEV, a new Epstein-Barr virus negative Burkitt's lymphoma derived cell line has been studied. Karyotype analyses demonstrated the t (8; 14) characteristic translocation. Cell surface characterisation of this line showed the presence of μ and x immunoglobulin chains and β2-microglobobulin and the absence of the complement receptor. We are unable to detect HLA-A, B alloantigens on the cell surface which was in contrast with an apparently normal expression of these antigens in the cytoplasm.