Post-operative Renal Failure, Shunt Type and Mortality after Norwood Palliation.

Abstract Background The Single Ventricle Reconstruction (SVR) trial demonstrated increased risk of death or heart transplant one year post-Norwood in subjects randomized to Blalock-Taussig shunts (mBTS) compared to right ventricle-to-pulmonary artery (RV-PA) shunts. We used the SVR public use database to evaluate incidence and risk factors for post-operative renal failure and relationships between renal failure, shunt type and outcomes post-Norwood. Methods Post-operative renal failure was defined a-priori as a 3-fold rise in creatinine from baseline, or dialysis use, within 7 days of Norwood. We used multivariate logistic regression to evaluate risk factors for post-operative renal failure and Cox hazard regression to determine the association between post-operative renal failure and one-year post-Norwood mortality. Results Overall, post-operative renal failure occurred in 8.4% (46/544) with risk factors including receipt of a mBTS (aOR 3.3, p=0.02), low center volume (aOR 2.7, p=0.005), presence of ≥2 pre-op complications (aOR 4.0, p Conclusions Post-operative renal failure is common after Norwood and is independently associated with mortality. Although renal failure is more common after mBTS, the highest mortality risk with renal failure occurs after RV-PA shunt.