Ovarian epithelial borderline tumors in adolescent women:report of 7 cases

Objective To investigate clinicopathological features of ovarian epithelial borderline tumors(EBT)in girls younger than 20 years.Methods Seven girls younger than 20 years with EBT were admitted to our hospital between Jan 2000 and Dec 2006.Their clinical and pathological data were retrospective studied.Results The average age was 17.8 years(range 16 to 19 years).All cases were virgin and had regularly menstruation.The main symptoms were abdominal distention in 5 patients(71.4%,3 of them accompanied by abdominal pain),and abdominal pain in 4(57.1%)cases.They were found pelvic tumors by physical examination,with 7～30 cm(median 20 cm)in diameter.Cystic tumors with solid part were found in 6 of the 7 patients and a solid neoplasm was found in the other one by ultrasound.Frozen section examinations during operation were taken.All patients were treated by fertility-sparing surgery:6 unilateral salpingo-oophorectomy and one by cystectomy.The postoperative diagnosis were ovarian mucous borderline neoplasm(MBT)FIGO Ia in 4 cases(57.1%),ovarian serous borderline neoplasm(SBT)stage Ⅰa in 2 cases(28.6%),and SBT stage Ⅲc in 1 case(14.3%).They were followed up for 18~94 months(average 53.9 months).Six girls(85.7%)were alive free of disease and 3 of them were alive for at least 79 months.One patient with SBT stage Ⅰa treated by unilateral salpingo-oophorectomy recurred at the other ovary with staged Ⅲc SBT in 18 months.Conclusions Most ovarian epithelial borderline tumors in young women are stage Ia SBT or MBT.Patients of all stage EBT treated by conservative management present good prognosis.