A case report of multiple ovarian follicles growed in the progress of gonadotrophin-releasing hormone agonist down-regulation of in vitro fertilization-embryo transfer and literatures review

Objective To analyze the case that multiple ovarian follicles growed in the progress of gonadotrophin-releasing hormone agonist down-regulation when a patient received in vitro fertilization (IVF) and to discuss the significance of follicle-stimulating hormone receptor (FSHR) determination that will guide the clinical diagnosis and treatment in in vitro fertilization. Methods The literatures that published about FSHR, ovarian response and IVF were searched. Results We detected two polymorphyisms of FSHR in this patient. After reviewed the literatures we find that ovarian reaction is associated with FSHR polymorphyisms. Conclusion FSHR determination may have some cilinical significances to predict ovarian response in IVF. However, we should gather more data to prove this conclusion. Key words: Ovarian response; Fertilization in vitro;  Follicle-stimulating hormone receptor