Clinical Study on Influence of Chinese and Western Medicine on Monoamine Neurotransmitter of Depression Patients during Peri-Menopausal Period

Objective:The mechanism of Jieyu Jingxin Granules combined with fluoxetine treating depression during peri-menopausal period was discussed by observing the influence on HAMD depression scale,monoamine neurotransmitter and endocrine function.Methods:119 cases with depression during peri-menopausal period were randomly divided into observation group and control group.68 cases in observation group were treated with Jieyu Jingxin Granules combined with fluoxetine while 51 cases in control group with fluoxetine only.8 weeks was a course.HAMD depression scale scores before and after treatment in two groups were compared.5-HT,NE,E2,FSH and LH levels were measured and endometrial thickness was tested by type-B ultrasonic method.Results:The total effective rate in observation group was 95.58%(65/68),in control group was 88.23 %(45/51).4 weeks later,HAMD scores in two groups had obvious significance(P0.05).8 weeks later,5-HT level was decreased(P0.01),NE level was increased(P0.05),the ratio of 5-HT/NE was decreased(P0.05).Conclusion:Jieyu Jingxin Granules combined with fluoxetine has better effect than single fluoxetine,has strong regulation effect on neurotransmitter of depression patients during peri-menopausal period and has few side effects.The mechanisms may be related to regulating synthesis and release of monoamine neurotransmitter,coordinating neuroendocrine function and regulating reproductive endocrine function.This study provided basis reference for medication of depression during peri-menopausal period by quantitatively observing the diagnosis and effect.