Concentrations of Urinary 8-Hydroxy-2’-deoxyguanosine and 8-isoprostane in Women Exposed to Woodsmoke in a Cookstove Intervention Study in San Marcos, Peru

Background: Nearly half of the world’s population is exposed to household air pollution (HAP) due to long hours spent in close proximity to unvented cooking fires. Aims: To investigate whether woodsmoke exposure induces oxidative stress by examining the relationship between woodsmoke exposure and biomarkers of DNA oxidation (8-hydroxy-2’-deoxyguanosine [8-OHdG]) and lipid peroxidation (8-isoprostane) among control and intervention stove users. Methods:We conducted HAP exposure assessment within the framework of a community-randomized controlled trial of 51 communities in San Marcos Province, Cajamarca Region, Peru.The first morning urine voids after 48hr HAP exposure assessment were taken from a subset of 45 control and 39 intervention stove users, for whom PM2.5 and/or CO data were available, were analyzed for 8-OHdG and 8-isoprostane. Control households used a number of stoves including open fire and chimney stoves while intervention households used study-promoted OPTIMA chimney stoves. General linear m...