Application of microvesicles from bone marrow mesenchymal stem cells in preparing drug for treating kidney injury

The invention discloses application of microvesicles from bone marrow mesenchymal stem cells (MSCs) in preparing a drug for treating a kidney injury. According to the application, a recovery effect of the MVs (microvesicles) in a kidney fibration process is verified by in vivo experiments and in vitro experiments. Fibration of renal tubular epithelial cells is caused by TGF-beta1 in the in vitro experiments, the research indicates that the extends of a cell fibration lesion and a cell injury in an MV group are obviously reduced, a unilateral ureteral occlusion animal model is built, the research indicates that in an UUO (unilateral ureteral occlusion) mouse model, average levels of SCr (serum creatinine ), blood UA ( uric acid), urinary protein of an UUO mouse injected with the MVs fall remarkably, the further pathological observation indicates that the extent of the kidney tissue injury of the mouse is improved obviously, the extends of renal mesenchymal fibration, lymphocyte infiltration and renal tubular swelling and necrosis are reduced obviously, and the kidney histopathology grade falls remarkably. That the MSC-MVs have a kidney injury recovery effect on the mouse with the unilateral ureteral occlusion is proved.