Application of reasonable antiviral treatment of chronic hepatitis B in implementation of treatment goals in the guidelines

How to choose and use interferon (IFN) and nucleoside analogues (NAs) to achieve the chronic hepatitis B the treatment goals, and the mechanism and characteristics of the two kinds of drugs were investigated. In order to gradually achieve the satisfied even the ideal milestone, it needs combination and sequential application of interferon therapy at the right time through evaluating and monitoring the changes of HBsAg and HBeAg quantity. Reasonable antiviral therapy could improve the efficacy of chronic hepatitis B to the maximum extent. Key words: Chronic hepatitis B; Sequential therapy; Combined therapy; Antiviral therapy