Burden of acromegaly in the United States: Increased health services utilization, location of care, and costs of care.

BACKGROUND Limited information is available on the utilization and healthcare costs among patients with acromegaly. The purpose of this study was to assess the impact of acromegaly on healthcare utilization and costs by locations of care (LoC). METHODS Patients with acromegaly and controls were identified from an analysis of drug and medical claims filed from January 2010 to April 2019 from a US employer database. Each patient with acromegaly was matched with 20 random controls (without acromegaly) selected from the database. Claims were tracked for 12 months postdiagnosis (or matched date for controls). Outcomes by LoC, including costs, services, and likelihood of use, were compared using 2-stage regression models or logistic regression models, controlling for demographic and job-related variables, and Charlson comorbidity index scores. RESULTS Claims from 60 patients with acromegaly and 1200 controls were analyzed. Compared with the control group, patients with acromegaly had significantly higher likelihoods of receiving care in a physician's office [odds ratio >1000], inpatient [OR =8.010], outpatient [OR =12.656], laboratory [OR =3.681], and 'other' locations [OR =4.033] (all p < 0.001), except in an emergency department (ED). Significantly more services were performed at each LoC for those with acromegaly (p < 0.01) but not in an ED. Total costs were more than 5-fold higher for the acromegaly cohort compared with controls (p < 0.05). Costs by LoC were consistently higher (p < 0.001) for patients with acromegaly vs. controls, with mean annual cost differences greatest in outpatient hospital/clinic ($9,611 vs $1,355), inpatient ($8,646 vs $739), physicians' office ($4,762 vs $1,301), other ($2,001 vs $367), and laboratory ($508 vs $66). ED-related treatment costs were not significantly different between cohorts. CONCLUSIONS Compared with matched controls, patients with acromegaly were more likely to utilize healthcare services in nearly all LoCs and accrue higher expenditures at each LoC, with the exception of ED services.