Non-invasive evaluation of late cardiac toxicity in childhood cancer survivors

6047 Background: Our understanding of the relationship of echocardiographic abnormalities to clinical cardiovascular status in long-term childhood cancer survivors is deficient. Methods: Long-term childhood cancer survivors returning for annual follow-up were assessed by physical examination, laboratory (hemoglobin, thyroid function, and fasting lipid profile) evaluation, echocardiogram, and 12-lead and 24-hour electrocardiogram. Mean fractional shortening (FS) and afterload (AF) were compared for survivors who did (at risk) and did not (no risk) receive cardiotoxic therapy and to control values. Two sample t test and multiple regression analysis were used to analyze data. Results: Of 278 survivors studied, 237 were at risk and 41 at no risk for cardiotoxicity. Median age at diagnosis and evaluation was 4.7 years and 16.8 years; 50% were male and 81.7% Caucasian. The median dose of anthracycline was 195 mg/m2. None of the patients had clinical cardiac dysfunction. Mean FS (SD) was lower for at risk surviv...