Biochemistry, Immunoglobulin E (IgE)

Immunoglobulin E is one of the five classes of immunoglobulins (IgM, IgG, IgD, IgA, IgE). It was the last of the immunoglobulin family to be discovered, and since then has spurred vast amounts of research aimed at characterizing its biochemistry and role in disease processes. Not only does IgE have a unique chemical structure, but it also has an array of physiological functions such as Type I hypersensitivity reactions, parasitic infections, autoimmune processes, and even venom protection. There have also been advancements in technology used to evaluate patient IgE levels, in addition to new pharmacological therapies that may inhibit its function altogether. The following article aims to provide an overview detailing the biochemical structure and function of Immunoglobulin E, as well as some examples of its clinical implications.