Low-grade myofibroblastic sarcoma of mandible in an infant

Abstract Low-grade myofibroblastic sarcoma (LGMS) is a rare sarcoma characterized by myofibroblastic differentiation. LGMS can occur at various sites on the body but frequently occurs in the head and neck region, particularly the tongue. LGMS occurs in younger individuals compared to other tumors, but few LGMS cases have developed in early childhood. Wide excision is the first choice; there are a few reports of cases treated by chemotherapy and radiation therapy. Here we describe an extensive LGMS centering on the mandible of a Japanese male who was 1 year and 9 months old at his presentation. We successfully treated his LGMS by a combination of chemotherapy, radiotherapy and surgery.