Regulation of shear-induced nuclear translocation of the Nrf2 transcription factor in endothelial cells
2009
Background
Vascular endothelial cells (ECs) constantly experience fluid shear stresses generated by blood flow. Laminar flow is known to produce atheroprotective effects on ECs. Nrf2 is a transcription factor that is essential for the antioxidant response element (ARE)-mediated induction of genes such as heme-oxygenase 1 (HO-1). We previously showed that fluid shear stress increases intracellular reactive oxygen species (ROS) in ECs. Moreover, oxidants are known to stimulate Nrf2. We thus examined the regulation of Nrf2 in cultured human ECs by shear stress.
Keywords:
- Molecular biology
- Transcription factor
- Endothelial stem cell
- Biochemistry
- Human umbilical vein endothelial cell
- Biology
- Cell biology
- Signal transduction
- Response element
- Intracellular
- Reactive oxygen species
- Shear stress
- Cell culture
- Regulation of gene expression
- Cell nucleus
- Nitric oxide synthase
- Transcription (biology)
- Correction
- Source
- Cite
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