Relación entre el polimorfismo rs1414334 C/G del gen HTR2C y tabaquismo en pacientes tratados con antipsicóticos atípicos

espanolEn pacientes psiquiatricos, otros autores han encontrado una asociacion entre el alelo C del polimorfismo rs1414334 del gen HTR2C y el sindrome metabolico. Ninguno de ellos ha valorado si este alelo se asocia con el consumo de tabaco, por lo que se decidio realizar un estudio en una region espanola valorando esta cuestion. Estudio observacional transversal de una muestra de 166 pacientes adultos tratados con antipsicoticos atipicos en 2012-2013. Variable principal: presencia del alelo C del polimorfismo rs1414334 del gen HTR2C. Variables secundarias: numero de anos-paquete (numero de cigarrillos al dia x numero de anos fumando ÷ 20), edad, sexo, esquizofrenia, anos diagnosticados del trastorno, criterios de sindrome metabolico y SCORE. Se construyo un modelo de regresion logistica binaria por pasos para determinar asociaciones entre la variable principal y las variables secundarias del estudio y se calculo su area bajo la curva ROC (ABC). Del total de la muestra, 33 pacientes presentaron el alelo C del polimorfismo analizado (19,9%). El consumo de tabaco medio fue de 11.6 paquetes-ano. El modelo multivariante arrojo los siguientes factores asociados al polimorfismo: mayor consumo tabaquico, ser mujer y no tener obesidad abdominal. El ABC fue de 0,706. Se ha encontrado asociacion entre un mayor consumo de tabaco a lo largo de los anos y la presencia del alelo C del polimorfismo rs1414334 del gen HTR2C. Se necesitan trabajos que corroboren nuestros resultados. EnglishAn association has been found between the C allele of the rs1414334 polymorphism in the HTR2C gene and the metabolic syndrome in psychiatric patients. However, no study has yet evaluated whether this allele is associated with smoking. To assess this issue, therefore, we performed a cross-sectional study with a sample of 166 adult patients treated with atypical antipsychotics in 2012-2013 in a region of Spain. The primary variable was the presence of the C allele of the rs1414334 polymorphism in the HTR2C gene. Secondary variables were the number of pack-years (number of cigarettes per day x number of smoking years ÷ 20), age, gender, schizophrenia, years since diagnosis, metabolic syndrome criteria and SCORE. A stepwise binary logistic regression model was constructed to determine associations between primary and secondary variables and their area under the ROC curve (AUC) was calculated. Of the total sample, 33 patients (19.9%) had the C allele of the polymorphism analyzed. Mean cigarette consumption was 11.6 pack-years. The multivariate analysis showed the following factors as associated with the polymorphism: higher cigarette consumption, being a woman, and not having abdominal obesity. The AUC was 0.706. An association was found between increased cigarette consumption over the years and the presence of the C allele of the rs1414334 polymorphism in the HTR2C gene.