Association of HLA loss of heterozygosity with allele-specific neoantigen expansion in response to immunotherapy.

Rachel Marty Pyke,Charles Abbott,Steven Dea,Nikita Bedi,A. Dimitrios Colevas,Eric Levy,Simo V. Zhang,Michael Snyder,Datta Mellacheruvu,John B. Sunwoo,Richard Chen,Sean Michael Boyle

Association of HLA loss of heterozygosity with allele-specific neoantigen expansion in response to immunotherapy.

2021

Rachel Marty Pyke
Charles Abbott
Steven Dea
Nikita Bedi
A. Dimitrios Colevas
Eric Levy
Simo V. Zhang
Michael Snyder
Datta Mellacheruvu
John B. Sunwoo
Richard Chen
Sean Michael Boyle

e18030Background: Human leukocyte antigen loss of heterozygosity (HLA LOH) restricts immune recognition of tumors by limiting the major histocompatibility complex (MHC) presentation of neoantigens ...

Keywords:

Medicine
allele specific
Limiting
Major histocompatibility complex
Immunology
immune recognition
Immunotherapy
Loss of heterozygosity
Human leukocyte antigen

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