Periodontal destruction and trends in periodontal treatment for patients

Abstract Periodontal diseases are chronic inflammatory disorders caused by the accumulation of a bacterial biofilm, characterized by the destruction of periodontal tissues, and result in loss of tooth. Recently, a part of mechanism of alveolar bone destruction has been revealed with advances in osteoimmunology. Here, we review the possible mechanisms of periodontal destruction. In addition, we described future outlook of our translational research for periodontal regenerative medicine.