Memory performance of hypercholesterolemic mice in response to treatment with soy isoflavones

Abstract The aim of this study is to investigate the memory performance of hypercholesterolemic mice in response to soy isoflavones (SI) treatment and the mechanism involved. In this study, 64 mice were randomly divided into four groups: control, high lipid diet without SI, high lipid diet with a low SI level (50 mg/kg bw) and high lipid diet with a high SI level (100 mg/kg bw). The experimental period was 30 days. The results indicated that the mice given the different treatments showed the different percentages of good, medium and poor memory performance. χ 2 analysis revealed significant difference in memory performance ( P versus high lipid diet with a low SI level group or high lipid diet with a high SI level group, P versus high lipid diet with a low SI level group or high lipid diet with a high SI level group, P