Bullous pemphigoid with IgG autoantibodies to BP180 C-terminal domain and desmocollin 3 associated with transverse colon cancer.

An 82-year-old Japanese male presented erythemas and blisters with atrophic scars on the abdomen, lower back, buttocks and legs (figure 1A,B). No mucosal lesion was seen. A skin biopsy revealed subepidermal blisters with infiltration of a few eosinophils, lymphocytes and histiocytes in the dermis. Shrunken keratinocytes with dense nuclei and clear cytoplasm, suggesting apoptotic cells, without apparent acantholysis were also observed in epidermis (figure 1C,D). The results of IgG enzyme-linked immunosorbent [...]