Renal neuroadrenergic effects. Part II. Experimental model and results

The stimulation of renal innervation activates vasoconstrictor mechanisms that compromise the parenchyma. In order to know the intensity and duration of these effects continuous electric stimulation was applied to the greater splanchnic nerve in 14 dogs for half an hour, completing both a pre and post monitoring of equal duration; creatinine clearance (Crc) and urine volume per minute (UVM) were determined; blood pressure (BP), heart rate (HR), respiratory rate (RR), and also central venous pressure (CVP) in 7 animals were permanently recorded. Crc and UVM significantly decreased during the initial 10 minutes stimulation (p < 0.001); over the following 10 minutes only Crc decreased (p < 0.01) and during the final 10 minutes there were no differences in the two controls. BP declines significantly during the first 10 minutes of stimulation (p < 0.001), but then increased for the remaining 20 minutes to values that showed no significant differences relative to measurements during monitoring pre- and post-stimulation. CVP, HR and RR recordings showed no significant differences from the two controls, relative to each other or to the period of stimulation after the maximum initial effects have disappeared.