The mechanism of Huanglian-Ejiao Decoction in the treatment of insomnia based on network pharmacology

Objective By taking network pharmacology approach to search for active components and the rapeutic targets of Huanglian-Ejiao Decoction. Methods According to the pharmacokinetic parameters, this research screened components of this decoction, and diged the drugs and disease targets with network pharmacology and constructed the drug-target-pathway network by Cytoscape system to investigate the mechanism of Huanglian-Ejiao Decoction. Results It was found that 19 components such as hydroberberine, β-sitosterol, curcumin, kaempferol, berberine and Ramie flavonoids in Huanglian-Ejiao Decoction could take effecton insomnia by regulating 25 targets such as 5-hydroxytryptamine, dopamine, gamma aminobutyric acid, opioid receptor and acetylcholine. Conclusion Huanglian-Ejiao Decoction may play an important role in treating insomnia by regulating multiple-targets. Key words: Huang Lian E Jiao Tang; Insomnia; Network pharmacology; Gamma-aminobutyric acid receptor; 5-hydroxytryptamine receptor