Neutrophil/lymphocyte ratio as a predictive value for overall survival in locally advanced breast cancer patients receiving neoadjuvant chemotherapy at the National Cancer Institute of Mexico.

e12023Background: The neutrophil-to-lymphocyte ratio (NLR) is a strong predictor of mortality in patients with pancreatic, colorectal, lung, gastric cancer and renal cell carcinoma. The aim of this study was to determine the relationship between pathological complete response (pCR) and pretreatment NLR values with overall survival in locally advanced breast cancer (LABC) patients receiving neoadjuvant chemotherapy (NACT) at the National Cancer Institute (NCI) of Mexico. Methods: Data were retrospectively collected from the Database of the NCI for LABC patients treated with NACT (including trastuzumab for HER2+ tumors) between January 2007- December 2010. We evaluated data of 690 patients (pts). Patients without complete pathology reports, laboratory test results, inflammatory (T4d) or pregnancy related BC were excluded. Pts who were diagnosed with chronic liver disease, end stage renal disease or any inflammatory disease such as SLE were also excluded. The pretreatment blood count data was retrieved from ...