EACPT-0046—A XENObIOTIC-INduCEd HEPATOTOXICITY ANd AN INfLuENCE Of HLA TYPIzATION

EACPT-0046—A XENObIOTIC-INduCEd HEPATOTOXICITY ANd AN INfLuENCE Of HLA TYPIzATION M. Zunic; D. Zunic; and R. Jesic Anesthesiology Intensive Care and Pain Therapy, UKC Maribor, Maribor, Slovenia; Infectology Unit, SB Murska Sobota, Murska Sobota, Slovenia; and Department for Gastroenterology Hepathological Unit, KBC Srbija, Beograd, Slovenia Summary: The increased reporting of cases of drug-induced liver injuries reflects the growing number of new agents introduced into clinical practice in the last decade. The aim of this study was to determine the most common causes of drug-induced liver injury in our surroundings. We analyzed 52 patients with a diagnosis of hepatotoxic liver injury (medical history, detailed clinical evaluation of patients, histopathologic analysis of the liver, abdominal ultrasound, and laboratory determination of standard liver function tests) and followed up for 12 months. Liver functional test results and morphologic findings were monitored. We used biologic markers relevant for the differential diagnosis, monitoring of disease progression, and response to therapy. The causes of toxic liver damage in our study included the following agents, classified into groups: industrial toxins (8 patients), food and beverages (9 patients), anti-rheumatic agents and analgesics (6 patients), antiarrhythmic drugs (4 patients), antilipemic agents (4 patients), antibiotics (4 patients), vitamins (3 patients), antihypertensive drugs (3 patients), antiplatelet drugs (2 patients), anticonvulsants (2 patients), drugs for osteoporosis (2 patients), antihypertensive drugs (1 patient), oral antidiabetic agents (1 patient), oral contraceptives (1 patient), glucocorticoids (1 patient), and antidepressants (1 patient). We obtained the results of HLA typing for 29 of the 52 patients with hepatotoxic liver injury and for 22 of 52 patients with chronic viral hepatitis. The paper points to hepatotoxicity, which is not rare in our population. Structure of xenobiotic agents causing liver toxicity in our environment is mainly industrial toxins, as well as food and beverages, more than drugs. Disclosure of Interest: None declared.