Reduced BNT162b2 mRNA vaccine response in SARS-CoV-2-naive nursing home residents.

David H. Canaday,Lenore L. Carias,Oladayo A Oyebanji,Debbie Keresztesy,Dennis Wilk,Mike C. Payne,Htin Aung,Kerri St. Denis,Evan C Lam,Christopher F. Rowley,Sarah D. Berry,Cheryl M. Cameron,Mark J. Cameron,Brigid Wilson,Alejandro B. Balazs,Stefan Gravenstein,Christopher L. King

Reduced BNT162b2 mRNA vaccine response in SARS-CoV-2-naive nursing home residents.

2021

David H. Canaday
Lenore L. Carias
Oladayo A Oyebanji
Debbie Keresztesy
Dennis Wilk
Mike C. Payne
Htin Aung
Kerri St. Denis
Evan C Lam
Christopher F. Rowley
Sarah D. Berry
Cheryl M. Cameron
Mark J. Cameron
Brigid Wilson
Alejandro B. Balazs
Stefan Gravenstein
Christopher L. King

After BNT162b2 mRNA vaccination, antibody levels to spike, receptor binding domain (RBD) and virus neutralization were examined in 149 nursing home (NH) residents and 110 health care worker controls. SARS-CoV-2-naive NH residents median post-2nd vaccine dose antibody neutralization titers are ¼ that of SARS-CoV-2-naive healthcare workers.

Keywords:

Immunology
Titer
Neutralization
Geriatrics
Antibody
Vaccination
severe acute respiratory syndrome coronavirus 2
Messenger RNA
Medicine
nursing homes

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