Impact of tricuspid regurgitation on survival in patients with cardiac amyloidosis

Background Tricuspid regurgitation (TR) is a common finding and has been associated with poorer outcome in patients with heart failure. Purpose This study sought to investigate the prognostic value of TR in patients with cardiac amyloidosis (CA). Methods Two-hundred and eighty-three patients with CA – 172 (61%) wild-type transthyretin–amyloidosis (ATTRwt) and 111 (39%) light-chain amyloidosis (AL) – were consecutively enrolled between December 2010 and September 2019. Transthoracic echocardiographies at time of diagnosis were reviewed to establish the presence and severity of TR and its relationship with all-cause mortality during patients’ follow-up. Results Seventy-four (26%) patients had a moderate-to-severe TR. Moderate-to-severe TR was associated with NYHA status (P  Conclusion Moderate-to-severe TR is frequent in CA and it is an independent prognosis factor in patients with ATTRwt but not in patients with AL.