Changes of peripheral blood chromosomal centromere aberration in patients with cytomegalovirus infection after anti-viral treatment

Objective To study the changes of peripheral blood chromosomal centromere aberration in patents with cytomegalovirus (CMV) infection after anti-viral treatment. Methods Sixty-two patients with early spontaneous abortion and CMV infection analyzed for their peripheral blood chromosomal centromere using simultaneous silver staining before and after anti-viral treatment. Results The patients with CMV infection had high rate of centromere aberration, which was decreased significantlyafter anti-viral treatment (P0.0001). Conclusion CMV infection is a risk factor for peripheral blood chromosomal centrimere aberration. Anti-viral treatment can decrease the rate of centrimere aberration aberration. Detection of peripheral blood chromosomal centrimere aberration allows the assessment of the severity of infection and the condition after treatment.