Segmentation and volumetric measurement of renal cysts and parenchyma from MR images of polycystic kidneys using multi-spectral analysis method
2008
For segmentation and volume measurement of renal cysts and parenchyma from kidney MR images in subjects with
autosomal dominant polycystic kidney disease (ADPKD), a semi-automated, multi-spectral anaylsis (MSA) method was
developed and applied to T1- and T2-weighted MR images. In this method, renal cysts and parenchyma were
characterized and segmented for their characteristic T1 and T2 signal intensity differences. The performance of the MSA
segmentation method was tested on ADPKD phantoms and patients. Segmented renal cysts and parenchyma volumes
were measured and compared with reference standard measurements by fluid displacement method in the phantoms and
stereology and region-based thresholding methods in patients, respectively. As results, renal cysts and parenchyma were
segmented successfully with the MSA method. The volume measurements obtained with MSA were in good agreement
with the measurements by other segmentation methods for both phantoms and subjects. The MSA method, however, was
more time-consuming than the other segmentation methods because it required pre-segmentation, image registration and
tissue classification-determination steps.
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