Comparative metabolomic study between African and Amazonian Symphonia globulifera by tandem LC–HRMS

Abstract According to the literature, the phytochemistry of Symphonia globulifera (Clusiacea) seems to be highly correlated to the local ecosystem. None of the already isolated 31 metabolites from Africa were common with the 13 isolated in French Guiana. Considering the potent therapeutic activities of these metabolites, we have investigated these differences thought a LC–HRMS n conducted metabolomic approach. By using a database correlation and fragmentation patterns, 37 compounds responsible of the variation have been putatively annotated. Among these metabolites, only 6 were already described in this species. This study highlights the relatively restrict phytochemical knowledge of Symphonia globulifera , a species with potent therapeutic metabolites and thus, allow faster phytochemical mapping for further isolation.