THU0429 THE ASSOCIATION OF SERUM VITAMIN A, VITAMIN E, AND FOLATE WITH HYPERURICEMIA: AN ANALYSIS OF POPULATION-BASED NATIONALLY REPRESENTATIVE DATA

Background: Hyperuricemia is an important risk factor for gout as well as hypertension, type 2 diabetes and renal impairment. Although previous studies investigated the association of questionnaire-based micronutrient intake with serum uric acid levels, limited data on serum micronutrients levels in relation to the risk of hyperuricemia especially in Asian population. Objectives: This study aimed to evaluate the association of serum vitamin A, vitamin E and folate level with hyperuricemia in the Korean general population. Methods: The present study included 6023 participants (2722 men and 3301 women) aged ≥19 years with available data on serum vitamin A, vitamin E, folate and serum uric acid. General characteristics of participants were compared using the Chi-square test and Student’s t test. The association between serum vitamin A, E and folate and serum uric acid levels were evaluated using general linear regression model. Multivariate logistic regression analyses were performed to estimate the effects of these micronutrients on hyperuricemia. Results: Serum uric acid levels were increased from the lowest quintile of vitamin A levels to the highest quintile after adjustment for covariates (P trend Conclusion: This study suggested that vitamin A could be a risk factor of hyperuricemia and further studies are warranted to elucidate underlying mechanism of the observed findings. References: [1]Choi, Woo-Joo, et al. “Independent association of serum retinol and β-carotene levels with hyperuricemia: A national population study.” Arthritis care & research 64.3 (2012): 389-396. Disclosure of Interests: : None declared