How to Reduce the Ischemic Brain Damage Secondary to Severe Head Injury

Head injury represents the cause of injury deaths in 50–70% of cases and is the main cause of death in the group under 20 years of age. Brain sequelae are often so severe as to hinder a satisfactory social reintegration. Prevention and control of the extension of the secondary cerebral lesions are important. Ischaemia has been recognized as the common final pathway in post-traumatic brain damage and seems to be mainly due to acute intracranial hypertension and decreased cerebral perfusion pressure (CPP) [3].