Association between PSA density and prostate cancer in men without significant MRI lesions

: The 2019 European guidelines for prostate cancer recommend to omit biopsy when multiparametric magnetic resonance imaging (mpMRI) of the prostate shows no significant lesions (i.e. PI-RADS ≤2) and clinical suspicion of prostate cancer is low. However, it remains unclear how to define "low clinical suspicion" and one might assume, that clinical suspicion is usually more than low if a costly investigation such as MRI is ordered.