A simple SCID mouse model for HIV research

Abstract The engraftment in SCID mice of human cells susceptible to HIV-1 infection was studied. Repopulation of various tissues by CD4 + human cells in transplanted SCID recipients was monitored via FACS, PCR, and immunohistology. Injection into SCID mice resulted in extensive proliferation of CD4 + cells in the peritoneal cavity, secondary lymphoid organs and other organs. The SCIDCD4 + mouse may provide a simple model system for in vivo research purposes such as HIV-1 infection, anti-HIV drug screening, and vaccine development.