Membrane insertion of—and membrane potential sensing by—semiconductor voltage nanosensors: Feasibility demonstration

2018 
We developed membrane voltage nanosensors that are based on inorganic semiconductor nanoparticles. We provide here a feasibility study for their utilization. We use a rationally designed peptide to functionalize the nanosensors, imparting them with the ability to self-insert into a lipid membrane with a desired orientation. Once inserted, these nanosensors could sense membrane potential via the quantum confined Stark effect, with a single-particle sensitivity. With further improvements, these nanosensors could potentially be used for simultaneous recording of action potentials from multiple neurons in a large field of view over a long duration and for recording electrical signals on the nanoscale, such as across one synapse.
    • Correction
    • Source
    • Cite
    • Save
    • Machine Reading By IdeaReader
    57
    References
    2
    Citations
    NaN
    KQI
    []