SYNTHESIS AND PHARMACOLOGICAL SCREENING OF PYRAZOLOPYRIDINE COMPOUNDS AS ANXIOLYTICS

Amine & chloro derivatives of Ethyl 4 b)pyridine-5-carboxylate & carboxylic acid were synthesized usin g liquid ammonia & phosphorous oxychloride from 1-pentyl-5 amino pyrazole respectively. 3 amino Pyrazolo(4,3-c)pyridine-4,6-diol were synthesized from 3 pyrazole using a c t i v e m e t h yl e n e c o m p o u n d , M a l o n o n i t r i l e & s u b s t i t u t e d h yd r a z i n e Pyrazolo(3,4-b)pyridinone was synthesized from 3 Completion of reactions was checked by TLC using hexane:ethyl acetate as mobile phase. Reagents like Diethyl Benzoyl malonate & β- compounds were characterized by IR, Mass & NMR analytically & by melting point & TLC physically. The synthesized compounds were tested using Elevated Plus Maze model. chloro derivatives of Ethyl 4 -substituted-6-phenyl-4,7-dihydro carboxylate & carboxylic acid were synthesized usin g liquid ammonia & phosphorous 5 amino pyrazole respectively. 3 amino -2 substituted diol were synthesized from 3 -cyanometyl-4-cyano a c t i v e m e t h yl e n e c o m p o u n d , M a l o n o n i t r i l e & s u b s t i t u t e d h yd r a z i n e b)pyridinone was synthesized from 3 -amino-1-phenyl p yrazolone & acetylacetone. Completion of reactions was checked by TLC using hexane:ethyl acetate as mobile phase. Reagents like -Cyano Ethylhydrazine were also synthesized. All the synthesized compounds were characterized by IR, Mass & NMR analytically & by melting point & TLC physically. The synthesized compounds were tested using Elevated Plus Maze model. ety, Pyrazolo(3,4 -b)pyridine, Pyrazolo(4,3-c)pyridine, P cyanoethyl hydrazine