T cell specific adaptor protein (TSAd) promotes interaction of Nck with Lck and SLP-76 in T cells

Cecilie Dahl Hem,Vibeke Sundvold-Gjerstad,Stine Granum,Lise Koll,Greger Abrahamsen,László Buday,Anne Spurkland

T cell specific adaptor protein (TSAd) promotes interaction of Nck with Lck and SLP-76 in T cells

2015

Cecilie Dahl Hem
Vibeke Sundvold-Gjerstad
Stine Granum
Lise Koll
Greger Abrahamsen
László Buday
Anne Spurkland

Background The Lck and Src binding adaptor protein TSAd (T cell specific adaptor) regulates actin polymerization in T cells and endothelial cells. The molecular details as to how TSAd regulates this process remain to be elucidated.

Keywords:

Cell biology
Jurkat cells
Proto-oncogene tyrosine-protein kinase Src
Actin
Signal transducing adaptor protein
SH2 domain
T cell
HEK 293 cells
Receptor
Biology
Immunoprecipitation

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