Mucohalic Acid in Lewis Acid Catalyzed Mukaiyama Aldol Reaction: A Concise Method for Highly Functionalized γ-Substituted γ-Butenolides.
2005
Abstract The first Mukaiyama aldol reaction on mucohalic acid ( 1a / b ) has been achieved. Reaction of 1 with various ketene silyl acetals or silyl enol ethers in the presence of a Lewis acid provides the γ-substituted γ-butenolides in good to excellent yield.
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