Neuroprotective effects of anti-high-mobility group box 1 antibody in juvenile rat hippocampus after kainic acid-induced status epilepticus.

High-mobility group box 1 (HMGB1) is a potent cytokine that has been proved to participate in diverse neurological diseases including seizures. Blockade of HMGB1 with neutralizing antibody has shown protective effects against different kinds of insults. However, the potential role of anti-HMGB1 anti