The prognostication potential of BRCA genes expression in gliomas: a genetic survival analysis study.

Abstract: Background Gliomas are the most common type of central nervous system tumor in adults, and they have an extremely poor prognosis. Gliomas are classified into four grades, with low-grade gliomas (LGG) encompassing grades I and II and glioblastoma multiforme (GBM) encompassing grade IV. BRCA genes play a role in DNA repair and are required for genome stability. Method We analyzed the LGG and GBM cohorts from The Cancer Genome Atlas. We used Kaplan-Meier and log-rank analysis to determine the relationship between BRCA1&2 expression and survival. Results BRCA1 & 2 expressions' correlation with survival in LGG patients was significant (p-value=0.00, p-value=0.00). The higher expression levels were, the lower survival rates were in both LGG and GBM patients, but the correlation was not significant in GBM patients (p-value Conclusion Our findings suggest that BRCA1 & 2 can be regarded as poor prognostic factors in patients with glioma, with greater significance in LGG. In the future, more in-depth experiments will enable us to elucidate the mechanism of gliomagenesis and identify potential gene therapy targets.